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CNS Pharmacology

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Pregunta:

C. Nefazodone and trazodone

Autor: Suzuki



Respuesta:

These drugs are weak inhibitors of serotonin reuptake. Their therapeutic benefit appears to be related to their ability to block postsynaptic 5-HT2A receptors. With chronic use, these agents may desensitize 5-HT1A presynaptic autoreceptors and, thereby, increase serotonin release. They are sedating, probably because of their potent H1-blocking activity. they are weak inhibitors of NE and 5-HT transporters their half-lives are short and usually require administration 2 or 3 times daily.


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Suzuki
Suzuki