Other drugs used for viral hepatitis

Telbivudine, a nucleoside analog, is phosphorylated by cellular kinases to the triphosphate form, which inhibits HBV DNA polymerase.The drug is at least as effective as lamivudine in chronic HBV infections and is similar in terms of its safety profile. Tenofovir, an antiretroviral drug, is also approved for chronic HBV infection and is active against lamivudine- and entecavir-resistant strains. Sofosbuvir inhibits RNA polymerase in HCV, alone or in combination with interferon or ribavirin and achieves very high cure rates (90–95%). Boceprevir is a protease inhibitor in HCV and is used in combination with ribavirin.