EFFECTS: CNS SYMPTOMS AT SUBANESTHETIC CONCENTRATIONS SIMILAR TO ALCOHOL INTOXICATION, EXTREMELY HIGH EXPOSURE: SENSITIZE THE MYOCARDIUM TO CATECHOLAMINES Metabolism and MOA: covalently BINDS HEPATIC & RENAL PROTEINS & LIPIDS which damages membranes and other extracellular structure, leading to NECROSIS & TUMOR FORMATION; USED IN THE PRODUCTION IN THE REFRIGERANT FREON; hepatotoxic and nephrotoxic;