• Synthetic anticoagulant, Selective inhibition longer half-life, less bleeding than LMW Heparins Therapeutic use • Prevention of DVT following surgery • Treatment of acute PE (in conjunction with warfarin) • Treatment of acute DVT (in conjunction with warfarin) Adverse effects • Bleeding • Patients weighing less than 50 kg • Thrombocytopenia • Spinal or epidural hematoma