Third-Generation Cephalosporins: Dosage/Route: Adult: 2-8 g/d IM or IV in divided doses q6-q8h; reduce dose with renal impairment Pediatric: 50-180 mg/kg/d IM or IV in divided doses q4-q6h Usual Indications: Treatment of moderate to severe sin, urinary tract, and respiratory tract infections; pelvic inflammatory disease; intra-abdominal infections; peritonitis; septicemia; bone infections; central nervous system (CNS) infections; preoperative prophylaxis