Locomotion steps

1) Locomotion begins with the extension of one or more Lamellipodia from the leading edge of the cell. This involves actin polymerisation which pushes the membrane forward. 2) New focal adhesions are established which involves capping of actin filament bundles at specialised sites on the plasma-membrane 3) The bulk of the cytoplasm is pushed forward by contraction of Actin-Myosin II bundles (stress fibres) at the rear of the cell in a process called Translocation. 4)The trailing edge of the cell detaches from the Extracellular matrix and retracts into the cell body. During this process the endocytic machinery internalises Integrins and transports them to the front of the cell to be used again.