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MCB L11-12

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Pregunta:

What happens to an ER protein that fails quality control? e.g., an MHC Class I HC that has failed to find β2m

Autor: Alex Rapai



Respuesta:

1. If the MHC Class I HC has a long residence time with ER chaperones 2. this allows access of a mannosidase that removes one particular mannose 3. removing this protein from the folding environment. 4. The protein is unfolded and fed through a multisubunit DISLOCON 5. and is ubiquitylated during dislocation, which targets it to the proteasome 6. where it is deubiquitylated and degraded.


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