Origins of replication

1. ORC detects the origin. 2. Binds and recruits Cdc6 and Cdt1 Steps 1-3 are G1 phase 3. They recruit Mcm helicase 4. Cdc6 gets phosphorylated and degraded. Steps 4-6 are S Phase 5. Phosphorylation of ORC 6. DNA replication 7. Normal with duplication Step 7 is G2,M phase