Major blood vessels that supply the heart with blood, oxygen and nutrients (coronary arteries) become damaged or diseased •Plaque formation in the arteries and inflammation causes coronary artery disease •Plaque formation causes coronary arteries to narrow which decreases blood flow to the heart. This leads to angina (chest pain), shortness of breath and other symptoms. Complete blockage can lead to a heart attack •Angina – the heart does not get enough arterial blood supply