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BBS2001 Threats and Defence Mechanisms

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Pregunta:

What happens in T-dependent B cell activation?

Autor: Mirte Schattorie



Respuesta:

1. the naive CD4 T cells are activated in the T cell zones and the naive B cells are activated in follicles, both by the same antigens 2. they migrate towards each other to the paracortical areas, because B cells express CCR7 and T cells express CXCR5 3. the B cells then present their antigens on the MHC-II molecules so that the T cells can recognize them 4. the T cells then express the CD40L and the B cells express CD40, they bind to each other and proliferation of the B cells occurs


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