What is the sequence of events for eccentric muscle damage

Unaccustomed exercise – uses eccentric muscle actions (downhill running, slowly lowering weights) Damage to sarcolemma – causes the release of cytosolic enzymes and myoglobin Damage to contractile structures Accumulation of metabolites – produce more cell damage and reduced force capacity Delayed onset muscle soreness (DOMS) – results from inflammation, tenderness or pain Healing and adaptation of muscle cells – adaptive process makes the muscle more resistant to damage from subsequent exercise.