What are some of the proteins affected by mutations that may block the maturation of T and B lymphocytes in human immunodeficiency diseases?

Janus kinase 3 (JAK3) is a kinase involved in signaling by many cytokine receptors; ARTEMIS is a protein involved in antigen receptor gene recombination; Bruton tyrosine kinase (BTK) is a kinase that delivers signals from the pre–B cell receptor and BCR; ZAP70 is a kinase involved in TCR signaling; and TAP proteins transport peptides for presentation by class I MHC molecules. ADA, Adenosine deaminase; CLP, common lymphoid progenitor; HSC, hematopoietic stem cell; PNP, purine nucleoside phosphorylase; RAG, recombination-activating gene; TCR, T cell receptor.