What are 2 causes leading to increase in the size of the contents running through the tunnel that are chronic in nature?

- Repetitive actions of the wrist (swelling, as well as thickening of fibers via use growth and fibrosis) - Scar Tissue (injury) - Conditions that result in edema & fluid retention or connective tissue degeneration (diabetes, hypothyroidism, rheumatoid arthritis & pregnancy)