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level: Rheumatology 4 - Lecture 7

Questions and Answers List

Rheumatology 4

level questions: Rheumatology 4 - Lecture 7

QuestionAnswer
What is the most common connective tissue disease?What of disease is Systemic Lupus Erythematosus?
Organ failure, or overwhelming sepsis cause premature death. As well as cardiovascular disease to which chronic steroid therapy makes a major contribution.What causes premature death in Systemic Lupus Erythematosus?
5 YearsWhat is the mortality time for Systemic Lupus Erythematosus?
Vasculitis and organ damage are part of active (what disease)?Immune complex formation is thought to be an important mechanism of tissue damage in active SLE, leading to widespread (2 answers)?
General symptoms: fever, weight loss and mild lymphadenopathy. Also has a raised, sore and itchy rash (often "butterfly" facial rash.Clinical Features of Systemic Lupus Erythematosus
What is "Raynaud's phenomenon"?___________ is a condition resulting in discoloration of the fingers and/or the toes after exposure to changes in temperature (cold or hot) or emotional events.
Is swelling, that is raised and painful or itchyWhat is erythematous?
Refers to various conditions in which there is mottled discolouration of the skin. It is described as being reticular (net-like, lace-like), as cyanotic discolouration surrounds pale central skin.What is livedo reticularis?
- Subacute cutaneous lupus erythematosus (SCLE) rashes are migratory, non-scarring and either annular or psoriaform. - Discoid lupus lesions are characterized by hyperkeratosis (dermal thickening) and follicular plugging, and may cause scarring alopecia (spotty balding).What is the difference between Subacute cutaneous lupus erythematosus (SCLE) and Discoid lupus?
Systemic Sclerosis(_____________) is a generalised disorder of connective tissue affecting the skin, internal organs and vasculature.
4th and 5th life decades. Women.What are the main decades of life that see the highest peak in Systemic Sclerosis? Which gender is most effected"
Thinning of the lips and radial furrowing (vertical lines around the mouth), discolouration of the ends of fingers, and shiny, taught skin over fingers with restricted ROM.What are the symptoms of Systemic Sclerosis found in the face and hands?
- Arthralgia, morning stiffness. Restricted hand function is due to skin disease.What are the musculoskeletal features of Systematic Sclerosis?
Comes from the Greek arthro-, joint + -algos, pain) literally means joint pain.What does "Arthralgia" mean?
Definition: This is a heterogeneous group of diseases characterized by inflammation and necrosis of blood vessel walls, with associated damage to skin, kidney, lung, heart, brain and gastrointestinal tractWhat are the The Vasculitis Syndromes?
________ is usually classified on the basis of the size of vessel involved (Sm/M/L)Vasculitis is usually classified on the basis of _____________ involved
 local tissue ischaemia (due to vessel inflammation and narrowing) and  the systemic effects of widespread inflammation. These are the clinical features of what group of diseases?Pathophysiology : The clinical features of vasculitis result from _____________ (2)?
________ is a restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive).What does "ischaemia" mean?
Giant Cell Arteritis AND polymyalgia rheumatica (head and neck area with muscle pain), Takayasu’s arteritis (heart),Name 1 large-vessle vasculitis.
Kawasaki's Disease (heart), Classical polyarteritis nodosa (multisystem disease)Name 1 medium-vessle vasculitis.
Microscopic polyangiitis, Wegener’s granulomatosis (skull sinuses/upper respiratory/kidney), Churg–Strauss syndrome (respiratory/skin), Henoch-Schönlein purpura (usually begins with respiratory infection), Mixed essential cryoglobulinaemia (Cryoglobulins--immunoglobulins)Name 1 small-vessle vasculitis.
Nasal (and sinus cavities), respiratory, skin, renalIn Vasculitises, what body parts are often concerned?
Behçet’s syndrome is what?What is the Vasculitis with unknown etiology (size), that targets venules?
The study of the (medical) causes of an illness.Define Aetiology/Etiology