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level: VIDEO LEC 3

Questions and Answers List

level questions: VIDEO LEC 3

QuestionAnswer
Are used alone or in combination and must be accompanied by lifestyle modifications such as exercise and diet low in saturated fats.Statins, Niacin, Fibrates, Bile acid-binding resins, A cholesterol absorption inhibitor and Omega-3 fatty acids
7 Agents of Statins1. Pitavastatin 2. Rosuvastatin 3. Atorvastatin 4. Simvastatin 5. Pravastatin 6. Lovastatin 7. Fluvastatin
MOA OF STATINSCompetitive inhibitor of HMG CoA reductase which is a rate limiting step in cholesterol synthesis and this leads to inhibition of de novo cholesterol synthesis and they deplete the intracellular supply of cholesterol then depletion of intracellular cholesterol causes the cell to increase the number of cell surface LDL receptors and that promotes the uptake of LDL from the blood.
plasma cholesterol is reduced by both __1 decreased cholesterol synthesis 2 increased LDL catabolism ALSO decreased triglyceride levels and may increased HDL cholesterol levels in some patients
are the most potent LDL cholesterol lowering state in drug1 Pitavastatin 2 Rosuvastatin 3 Atorvastatin followed by Simvastatin, Pravastatin, Lovastatin, Fluvastatin
Reduction of elevated total and LDL cholesterol levels to slow progression of __coronary artery disease
ANTIHYPERLIPIDEMIC DRUGS S/E:1 Elevated liver enzymes may occur, liver function must be evaluated before starting therapy and if the patient has symptoms 2 Myopathy and rhabdomyolysis, disintegration of skeletal muscles have been rarely reported. 3 The seven agents may increase the effect of warfarin and they are contraindicated during pregnancy and lactation
Usually in patients with renal insufficiency or taking drugs such as erythromycin, gemfibrozil, or niacin, __ levels should be determined in patients with muscle complaints.plasma creatinine kinase