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level: CARCINOGENIC AGENTS

Questions and Answers List

level questions: CARCINOGENIC AGENTS

QuestionAnswer
Protein of extracellular matrixLAMININ MOLECULE
Major component of the basal lamina of the basement membraneLAMININ MOLECULE
A protein network foundation for most organs of the bodyLAMININ MOLECULE
Thin fibrous extracellular matrix that separates the internal or external surface underlying the connective tissueLAMININ MOLECULE
Closing down or assembly of tumor cell to an organDISSOLUTION
Recruitment of normal cell to tumor cellINVASION
PREDISPOSITION TO CANCER:Geographic and racial factors, e.g. cancer of the skin; prone to caucasiansXeroderma pigmentosum
PREDISPOSITION TO CANCER:Environmental and cultural influences; Inhalation of dust leads tolung, hepatic cancer
PREDISPOSITION TO CANCER:Environmental and cultural influences; betel nut chewing leads tosquamous cell carcinoma
PREDISPOSITION TO CANCER:Babies, toddlers, geriatric patients; Patients with low resistanceAge and childhood cancer
PREDISPOSITION TO CANCER:Cancer na namamanaHeredity
PREDISPOSITION TO CANCER:Precancerous disorder that leads to cancerAcquired preneoplastic disorders
PREDISPOSITION TO CANCER:Precancerous disorder that leads to cancer; endometrial hyperplasia leads toendometrial carcinoma
PREDISPOSITION TO CANCER:Precancerous disorder that leads to cancer ; leukoplakia leads tosquamous cell carcinoma
CARCINOGENIC AGENTS (CHEMICAL):anti-cancer drugs but regrettably have been documented to induce lymphoid neoplasms, leukemia, and other forms of cancer.Direct-Acting Alkylating Agent
CARCINOGENIC AGENTS (CHEMICAL):Drug taken before chemotherapyDirect-Acting Alkylating Agent
CARCINOGENIC AGENTS (CHEMICAL):Weak carcinogensDirect-Acting Alkylating Agent
CARCINOGENIC AGENTS (CHEMICAL): examples of Direct-Acting Alkylating Agentcyclophosphamide, chlorambucil, bisulfan, melphalan
CARCINOGENIC AGENTS (CHEMICAL):Most potent carcinogensPolycyclic aromatic hydrocarbons
CARCINOGENIC AGENTS (CHEMICAL):Usually taken from cigarette smokingPolycyclic aromatic hydrocarbons
CARCINOGENIC AGENTS (CHEMICAL): examples of Polycyclic aromatic hydrocarbonsDihydrodiol epoxides
CARCINOGENIC AGENTS (CHEMICAL):strong electrophilic reactants and combine with nucleophilic sites in the target cells, including DNA, RNA, and proteinsDihydrodiol epoxides
CARCINOGENIC AGENTS (CHEMICAL):Carcinogenicity of these substances were exerted mainly in the liver where the ultimate carcinogen is formed by the intermediation of the cytochrome P-450 oxygenase systemsAromatic amines and Azo dyes
CARCINOGENIC AGENTS (CHEMICAL):Aromatic amines and Azo dyes; Leads to hepatocellular carcinomaAcetylaminofluorene and azo dyes
CARCINOGENIC AGENTS (CHEMICAL):Leads to bladder cancerBeta-naphthylamine
CARCINOGENIC AGENTS (CHEMICAL):Seen in aniline dye and rubber industriesBeta-naphthylamine
CARCINOGENIC AGENTS (CHEMICAL):Produced by plants and microorganismsNaturally occuring carcinogens
CARCINOGENIC AGENTS (CHEMICAL):produced by Aspergillus flovus from improperly stored grains and peanutsaflatoxin B1
CARCINOGENIC AGENTS (CHEMICAL):aflatoxin B1 leads tohepatic carcinogen
CARCINOGENIC AGENTS (CHEMICAL):formed in the GI tract of humansNitrosamines and amides
CARCINOGENIC AGENTS (CHEMICAL):It involves the microsomal P-450 oxygenase systemNitrosamines and amides
CARCINOGENIC AGENTS (CHEMICAL):Nitrosamines and amides; ultimate carcinogenAlkyl diazonium ions
CARCINOGENIC AGENTS (CHEMICAL):Nitrosamines and amides; carcinogenD-nitrosodienthanolamines
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; bronchogenic carcinomas, mesotheliomas, GI cancersAsbestos
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; Manufacturing, building, cement products, paper productsAsbestos
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; Used primarily to make polyvinyl chlorideVinyl chloride
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; hemangiosarcoma of liverVinyl chloride
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; cancer of the lungsChromium, nickel, and other metals
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; factories, inhalation of dustChromium, nickel, and other metals
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; Ingredients of beauty productsarsenic
CARCINOGENIC AGENTS (CHEMICAL):Miscellaneous Agents; skin cancerarsenic
physical or chemical agents that changes the genetic material, usually DNAMutagen
CARCINOGENIC AGENTS (RADIATION):Derived from the sunUltraviolet Rays
CARCINOGENIC AGENTS (RADIATION):inhibition of cell division, inactivation of enzymes, induction of mutation, and sufficient dosage killing the cellUltraviolet Rays
CARCINOGENIC AGENTS (RADIATION):The carcinogenecity of UV light is attributed to its formation of ________ in DNAPyrimidine dimers
CARCINOGENIC AGENTS (RADIATION):molecular lesions formed from thymine or cytosine bases in DNA via photochemical reactionsPyrimidine dimers
CARCINOGENIC AGENTS (RADIATION): cause squamous cell carcinoma, basal cell carcinoma, melanocarcinoma of the skin.Ultraviolet Rays
CARCINOGENIC AGENTS: Skin cancer was sustained by pioneers in the development of Roentgen raysIonizing electromagnetic and particulate radiation
CARCINOGENIC AGENTS (RADIATION): miners of radioactive elements in central Europe and Rocky mountain (USA)Lung cancer
CARCINOGENIC AGENTS (RADIATION): Leukemia, thyroid, breast, colon, and pulmonary carcinoma- survivors of A bomb dropped in Nagasaki and HiroshimaIonizing electromagnetic and particulate radiation
CARCINOGENIC AGENTS: Can transform virtually all cell types in vitro and induce neoplasms in vivo in both humans and experimental animalsRadiation
ONCOGENIC VIRUSES (DNA):Wart like apperancepapilloma viruses
ONCOGENIC VIRUSES (DNA):benign epithelial tumors, papillomas of the skinpapilloma viruses
ONCOGENIC VIRUSES (DNA):can act with immune deficiency and exposure to UV light to produce malignant changepapilloma viruses
ONCOGENIC VIRUSES (DNA):Etiologic agents of benign squamous papillomas and in some cases HPV-induced benign lesions progress to ___________squamous cell carcinomas
ONCOGENIC VIRUSES (DNA):Form of non-hodgkin's lymphoma in which cancer start in immune cells called B-cellsEpstein-Barr virus
ONCOGENIC VIRUSES (DNA):Recognized as the fastest growing human tumorEpstein-Barr virus
ONCOGENIC VIRUSES (DNA):It infects B cells by binding to the B cell-specific receptor for the third component of complement. The infected B cells are immortalized and can be propagated indefinitely in vitroundifferentiated nasopharyngeal carcinoma
ONCOGENIC VIRUSES (DNA):liver cancerhepatitis B virus
ONCOGENIC VIRUSES (DNA):The virus may have acted with the regenerative activity of liver cirrhosishepatitis B virus
DNA viruses causes ______ transformationneoplastic
allows complete viral replication but die upon release of newly formed virusPermissive cells
do not allow the virus to complete its life cycle, can be transformed into neoplastic cell due to integration of viral DNA Itto chromosome.Nonpermissive cells
one that allows a virus to circumvent its defenses and replicate; willing cellsCell/ host
Retrovirus-induced neoplastic transformation by insertional mutagenesis. A slow transforming virus infects a normal cell and integrates next to a proto- oncogenehuman T-cell leukemia virus
production of genetic mutation; Normal cells that when it is altered, becomes oncogeneinsertional mutagenesis
cause increase transcription of protooncogene productViral promoters