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level: Level 7 - DRUGS

Questions and Answers List

Question	Answer
lower blood pressure by reducing peripheral vascular resistance without reflexively increasing cardiac output, heart rate, or contractility.	ACE INHIBITORS (ACEIn)
Ace inhibitors block the enzyme __ the ACE which cleaves angiotensin I to form the potent vasoconstrictor angiotensin II.	peptidyl dipeptidase
recommended as first-line treatment of hypertension in patients with high coronary disease risk	Enalapril and lisinopril
is responsible for the breakdown of BRADYKININ, a peptide that increases the production of nitric oxide and prostacyclin by the blood vessels. Both are potent vasodilators. ACE inhibitors decrease angiotensin II and increase bradykinin levels.	ACE
cause coughing as its breakdown is prevented by ACEIn, it is a potent vasodilator Common S/E include dry cough, rash, fever, altered taste, hypotension (in hypovolemic states), and hyperkalemia The dry cough, which occurs in up to 10% of patients, is thought to be due to increased levels of this	bradykinin
a rare but potentially life-threatening reaction that may also be due to increased levels of bradykinin.	Angioedema
While on ACE Inhibitors, we should monitor __	1 Potassium Levels K supplements and K-sparing diuretics should be used with caution due to the risk of hyperkalemia. 2 Serum Creatinine Levels particularly in patients with underlying renal disease.
ACE inhibitors can induce __ and should not be used by pregnant women	fetal malformations