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Questions and Answers List

level questions: Moderate

QuestionAnswer
Lymphocytic leukocytosis resulting form EBV infection is comprised of what cells?reactive CD8+ T cells
Definitive test for kissing diseaseserologic testing to the EBV viral capsid antigen
Patients with infectious mononucleosis are generally advised contact sports for 1 year because it increases the risk for what?Spleenic Rupture
ALL is associated with what age group?children with Down syndrome AFTER the age of 5
Acute megakaryoblastic anemia is associated with what age group?children with Down syndrome BEFORE the age of 5
B-ALL cytogenic abnormality with a good prognosist(12;21)
B-ALL cytogenic abnormality with a poor prognosist(9;22)
chromosomes involved in the APLt(15;17)
chromosomes involved in CMLt (9;22) or Philadelphia Chromosome
chromosomes involved in Follicular Lymphomat(14;18)
chromosomes involved in Mantle cell lymphomat(11;14)
chromosomes involved in Burkitt's Lymphomat (8; 14)
Acute Myeloid Leukemia is associated with what age group?older adults 50-60 years old
common age group which by MPD appearslate adulthood 50-60 years
Complication of MPD due to high turnover of cellshyperuricemia and gout
BCR-ABL fusion has what kind of activity?tyrosine kinase activity
first line treatment in CML which blocks tyrosine kinase activityImatinib
this stain in positive in leukemoid reaction but not in CMLleukocyte alkaline phosphatase (LAP) stain
Mutation in PVJAK2 kinase
without treatment, death occurs in PV after how long?one year
distinguishes PV from reactive polycythemiadecreased erythropoietin levels
Histologic lymph node changes seen in patients with rheumatoid arthritis and early stages of HIV infectionFollicular hyperplasia (B-cell region)
Histologic lymph node changes seen in patients with viral infectionParacortex hyperplasia (T-cell region)
seen in lymph nodes that are draining a tissue with cancersinus histiocytes hyperplasia
overexpression of BCL 2 inhibits what?Apoptosis
present in serum protein electrophoresis which suggests multiple myelomaM-spike
M-spike is most commonly due to an increase in what types of ImmunoglobulinIgG or IgA
vitamin A derivative whiihc binds the altered RAR and causes the blasts to matureall-trans-retinoic acid (ATRA)