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level: Effects of Prostaglandins & Thromboxanes

Questions and Answers List

level questions: Effects of Prostaglandins & Thromboxanes

Question	Answer
a POTENT vasoconstrictor & smooth muscle cell mitogen, In VASCULAR SMOOTH MUSCLE the major product of COX-1 expressed in mature platelets • a platelet aggregator • also AMPLIFIES the effects of other, more potent platelet agonists such as THROMBIN	TXA2 Thromboxane A2
In SMOOTH MUSCLE, Vascular 1 also a vasoconstrictor 2 vasodilators;	. 1 PGF2α (Prostaglandin F2alpha) 2 PGI2 (Prostaglandin I2) & PGE2 (Prostaglandin E2)
Vasodilator in Smooth Muscle Vascular RELAXES Respiratory smooth muscle	PGI2 (Prostaglandin I2) & PGE2 (Prostaglandin E2)
most __ activate GIT smooth muscle	prostaglandins and thromboxanes
- Relaxes circular muscle In Gastrointestinal Tract - Low concentration of __ enhance platelet aggregation and vice versa	PGE2 (Prostaglandin E2)
very powerful bronchoconstrictors	Leukotrienes
Respiratory smooth muscle is relaxed by __ and contracted by __	1 Prostaglandin E2 (PGE2) and (PGI2) Prostaglandin I2 2 PGD2, TXA2 and PGF2α
In Kidneys, 1 Loop diuretics produce some of their effect by STIMULATING COX activity, thus should not be administered concomitantly with __ 2 causes INTRARENAL VASOCONSTRICTION	1 COX inhibitor 2) TXA2
In Female Reproductive Organs, 1 contract uterine smooth muscle 2 causes relaxation	. 1) PGF2α, TXA2 & low concentrations of PGE2 2) High concentration of PGE2
In Male Reproductive Organs, 1 Men with low seminal fluid concentration of __ are relatively infertile 2 enhance penile erection	1 prostaglandins 2 Smooth muscle relaxing prostaglandins such as PGE1