| 3 METHODS AS SAMPLE PREPARATION: | 1 Dispersing finely ground solid in liquid petrolatum (MULL TECHNIQUE)
2 Dissolving solid in organic solvent
3 Incorporating solid in KBr pellet |
| Dispersing finely ground solid in liquid petrolatum (MULL TECHNIQUE)
PROCESS | - 100 mg spl
- Place in agate mortar and pestle
- Grind
- Add drops of liq. petrolatum and ground
- mull is formed
- Transfer to NaCl plates
- Absorption/transmittance spectrum is then run
- Repeat w/ ref. std. |
| Dissolving solid in organic solvent
organic solvents used: | (width of 1nm)
CHCl3
CS2 |
| Incorporating solid in KBr pellet
PROCESS | 1. 5 mg spl
2. add 500 mg ir quality KBr in mortar and pestle
3. mix
4. transfer about 200 mg mixture to compression chamber
5. compress mixture at 20,000lb for 10 min.
6. remove the pellet
7. transfer to holder
8. obtain absorption spectrum
9. same procedure using ref. std. |
| For liquid samples, a thin layer of subst. is placed directly between __ | NaCl plates (neat or straight samples) |
| A more recent development in sample preparation is the use of __ | diffuse reflectance |
| is another recent development in sample handling.
sample may be run in a gel or cream, and this method may be used to characterise both formulation matrices and their interactions with the drugs present in them. | Attenuated total reflectance (ATR) |
| OTHER APPLICATIONS OF IR: | 1 IR filters (night vision goggles)
2 Thermography (thermographic cameras)
3 Tracking or IR homing
4 Heating (sauna, de icing, cooking)
5 Communication (IR data transmission) |
| 1 these waves are thermal
2 these waves are not hot at all | 1 Far IR
ex. heat from sunlight
2 Near IR
ex. TVs remote control |
| The warmer the object, the __ IR radiation it emits: | more
ex. hot charcoal may not give off light but it emits IR radiation w/c use fuel as heat,
rattlesnakes have sensory used to image IR light thus detecting warm blooded animals even in dark |
