| Alpha-1 Antagonists Adverse Effect | • First Dose Syncope/Phenomenon -
sudden decrease in BP after taking
the drug
• Should be taken with lower dose at
bedtime |
| Effects on the Cardiovascular System PROPRANOLOL | • if given chronically can lower blood
pressure in patients with
hypertension
• valuable in the treatment of angina
pectoris, chronic heart failure and
myocardial infarction (negative
inotropic and chronotropic effect) |
| Effects on the Respiratory Tract PROPRANOLOL | blockade of β2-receptors in
bronchial smooth muscle will
increase in airway resistance,
particularly in asthma patients |
| Effects on the Eye PROPRANOLOL | • can reduce intraocular
pressure, especially in
glaucoma
• MOA: decreased aqueous
humor production |
| Metabolic & Endocrine Effects PROPRANOLOL | • can inhibit sympathetic
nervous system stimulation of
lipolysis
• can mask hypoglycemic signs
and symptoms |
| Adverse Effects PROPRANOLOL | • Bronchoconstriction
• Arrhythmias
• Sexual impairment
• Metabolic disturbances
• CNS Effects |
