| ATROPINE: EFFECTS ON EYES | 1 "mydriasis" (dilation of eye)
2 "cycloplegia" (weaken contraction of the ciliary muscles)
3 "Reduce Lacrimation" (Dry or sandy eyes) |
| ATROPINE: EFFECTS ON Gastrointestinal Tract | 1 XEROSTOMIA (Dry Mouth)
2 can reduce volumes and amount of
pepsin, acid and mucin
3 Antispasmodic
4 "Intestinal Paralysis"
5 RARELY used for peptic ulcer
6 can provide some relief in the
treatment of common traveler's
diarrhea and other conditions of
hypermotility |
| ATROPINE: EFFECTS ON Cardiovascular System | 1 Bradycardia: at LOW DOSE (slower heartrate)
2 Tachycardia: at HIGH DOSE (faster heartrate)
3 little effect on blood pressure |
| ATROPINE: EFFECTS ON Respiratory System | 1 BRONCHODILATION and Reduce Secretion
2 usually used in asthmatic and
COPD (Chronic Obstructive Pulmonary Disease) patients |
| ATROPINE: EFFECTS ON Genitourinary Tract | 1 Relaxes smooth muscles of the URETERS and BLADDER WALL
2 URINARY RETENTION |
| ATROPINE: EFFECTS ON Sweat Glands | 1 SUPPRESSES thermoregulatory SWEATING
2 "ATROPINE FEVER" in infants and children at ordinary dose |
| ATROPINE: EFFECTS ON Central Nervous System | 1 normal dose has MINIMAL stimulant effects on the CNS;
2 SLOWER, LONGER-LASTING SEDATIVE EFFECT
on the brain |
| Clinical Applications of Atropine | • Mydriatic & Cycloplegic agent
• Antispasmodic
• Treatment of bradycardia
• Antisecretory agent used before
surgery
• Antidote for cholinergic agonists
poisoning
MATAA |
| ADVERSE EFFECTS OF ATROPINE | • Dry mouth
• Blurred vision
• "Sandy Eyes"
• Tachycardia
• Urinary Retention
• Constipation
• CNS effects: restlessness, confusion, hallucination, delirium, depression, respiratory & Cardiovascular collapse, death
SIMILAR WITH SCOPOLAMINE |
| Atropine at more than 10mg Dose | Hallucinations and Delirium; Coma |
| Atropine at 5mg Dose | Rapid Heart Rate;
Marked DRYNESS OF MOUTH
Palpitations
Pupil Dilation
Blurring NEAR VISION |
| Atropine at 0.5mg Dose | Slight Cardiac Slowing;
Some Mouth Drying
Sweating Inhibition |
