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level: FOUR SUBTYPES OF RECEPTORS

Questions and Answers List

Question	Answer
Ionotropic receptors associated with ligand-gated ion channels Features: LOCATION = __ EFFECT = __	CLASS 1 LOCATION: Cell membrane EFFECT: millisecond
controls Na+ channels (Ligand-gated) -- inhibited by curare and derivatives, ganglionic blockers	Nicotinic Receptor (CLASS 1)
controls Cl- channels	GABAA-receptor complex (CLASS 1)
Metabotropic 7 transmembrane-spanning G-protein-linked Features: LOCATION = __ EFFECT= __	Class II LOCATION: Cell membrane EFFECT: Seconds
G-proteins: __	1) Gs 2) Gi 3) Gq
activates adenylyl cyclase which produces the second messenger cyclic adenosine monophosphate (cAMP)	Gs
inhibits adenylyl cyclase	Gi
activates phospholipase C generating two secondary messengers: 1,4,5- triphosphate (IP3) & diacylglycerol (DAG)	Gq
Enzyme-linked receptors • Features: EFFECT = __; possesses tyrosine kinase activity as part of their structure	Class III EFFECT: minutes to hours
CLASS III example	• Epidermal growth factor • Atrial natriuretic peptide • Insulin
• Intracellular receptors • Features: EFFECT = __	Class IV EFFECT: hours to days
Tubulin is the target of antineoplastic agents such as __	paclitaxel
the total number of cell-surface receptors is reduced, and the cell's responsiveness to ligand is correspondingly diminished because of the rapid degredation those receptors due to accelerated endocytosis	Down Regulation