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level: level 5

Questions and Answers List

level questions: level 5

Question	Answer
prodrugs of ampicillin	Hetacillin, Bacampicillin, Cyclacillin HBC
Similar to aminopenicillins in structure but have either carboxyl group or urea group instead of the amine	Extended Spectrum Penicillin/ Antipseudomonal penicillins
tx for systemic and UTI infections caused by P. aeruginosa, Proteus spp and Providencia spp, all are resistant to ampicillin. not stable in acids and inactivated by penicillinase given by IV US in 1970	Carboxypenicillins ( Carbenicillin, Ticarcillin) α- carboxybenzylpenicillin (Geopen, Pyopen)
slightly better p'kinetic prop> long DOA isostere of carbenicillin in which the phenyl group is replaced by thienyl group α-carboxy-3-thienylpenicillin (Ticar) greater invitro potency	Ticarcillin Sodium
much more active against Klebsiella spp, P. aeruginosa, H. influenzae not orally active	MEZLOCILLIN
Ureidopenicillins	Piperacillin-most potent, Azlocillin, Mezlocillin
more active than Mezlocillin most generally useful B-lactamases producing strains are resistant rapidly destroyed by stomach acid IV and IM admin only	Piperacillin Sodium
Class II inhibitor has potent antibacterial activity transient inhibition of some Beta lactamases	Carbapenem derivative Imipenem
Possess 2-hydroxyethylidene moiety at C-2 isolated from Streptomyces clavuligeris 1-oxopenam lacking the 6-acylamono side chain of pens acid- stable	Clavulanate Potassium BN: Augmentin, Timentin
Potentiates the activity of Ampicillin and Carbenicllin Penicillanic acid sulfone or 1,1-dioxopenicillanic acid	Sulbactam BN: Unasyn
similar structure to sulbactam more potent b-lactamase inhibitor than sulbactam slightly broader spectrum than clavulanic acid Combination with Piperacillin BN: Zosyn	Tazobactam
1 Tazobactam is combined with __	1 Piperacillin
Potent class of Beta lactams which attack wide range of PBPs, low toxicity and more resistant to beta lactamases than penicillins or cephalosporins	Carbapenems
isolated from Streptomyces cattleya One of the most broad spectrum antibiotics ever	Thienamycin
most successful derivative of thienamycin primary group is converted to nonnucleophilic basic function rapid degradation by renal peptidases	Imipenem-Cilastatin (BN: Primaxin) Cilastatin - inhibitor of DHP-I> longer DOA