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level: MODE OF ACTION OF DRUGS

Questions and Answers List

level questions: MODE OF ACTION OF DRUGS

QuestionAnswer
PIPERAZINE MOABlocks response of ascaris muscle to acetylcholine, causing flaccid paralysis in the worm, which is dislodge from the intestinal wall and expelled in the feces.
Pyrantel Pamoate MOADepolarizing neuromuscular blocking agent that causes spastic paralysis in susceptible helminths
Thiabendazole MOAInhibits helminth specific enzyme fumarate reductase, also arrest nematode cell division in metaphase by interfering with microtubule assembly. They exhibit a high affinity for tubulin, the precursor protein for microtubule synthesis.
Mebendazole MOAIrreversibly blocks glucose uptake in susceptible helminths, thereby depleting glycogen stored in the parasite. It also inhibits cell division in nematodes.
Oxamniquine MOAinhibit DNA, RNA and protein synthesis in schistosomes
Praziquantel MOAIncreases cell membrane permeability of susceptible worms, resulting in the loss of extracellular calcium. Massive contractions and ultimate paralysis of the fluke musculature occurs, followed by phagocytosis of the parasite.
IVERMECTIN MOAActivates glutamate-gated Cl channels and immobilizes parasite by tonic paralysis
NICLOSAMIDE MOAInhibits oxidative phosphorylation
DiethylcarbamazineImmobilize, alter surface structure of parasites making them susceptible to destruction
Benzimidazoles MOAInhibits microtubule synthesis by binding to B-tubulin Inhibit mitochondrial reductase Immobilize parasites