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level: level 2

Questions and Answers List

level questions: level 2

QuestionAnswer
Parent compound from which oxyquinoline have been derived8-hydroxyquinoline
1 The substitution of an __ at __ position of 8-hydroxyquinoline yields compounds with broad spectrum amebicidal activity1 iodide atom, 7
treatment for acute and chronic intestinal amebiasis, not in extraintestinal High incidence of topic neuropathy Should not be used routinely in Traveller's diarrheaIodoquinol
Direct amebicidal action in E. histolytica Protoplasmic poison that inhibit protein synthesis in protozoan and mammalian cells by preventing protein elongationEmetine and Dehydroemetine
1 Used in balantidial dysentery, fluke infestations (fascioliasis and paragonimiasis)1 Dehydroemetine
1 Emetine side effects 2 Compared to emetine, HAS LOWER INCIDENCE OF CARDIOTOXICITY, CDC1 GI Distress, Hypotension, arrythmia, Neuromuscular 2 Dehydroemetine
1 Treatment of pneumonia caused by P. carinii; Used as treatment and prophylaxis and treatment of African trypanosomiasis1 PENTAMIDINE ISETHIONATE
PENTAMIDINE ISETHIONATE Side Effects1 Cough, Bronchospasm, hypertension, hypoglycemia
1 Water insoluble analog of ubiquinone 6; Alternative to Trimethoprim-sulfamethoxazole Drugs Also treatment against P. carinii1 ATOVAQUONE
1 Atovaquone Side Effects 2 Atovaquone for absorption to increase 3 Atovaquone to prevent the emergence of resistance1 GI Intolerance 2 High fat content foods 3 Proguanil (potentiates malarial action)
Treatment of meningoencephalitic stage of west african sleeping sicknessEflornithine
1 Eflornithine Side Effects 2 What must be monitored when taking Eflornithine?Myelosuppressive drugs that causes 1 High incidence of anemia, Leukopenia, Thrombocytopenia 2 CBC (Complete Blood Count)
Treatment for T. CruziNifurtimox (Developed by Bayer 2502)
Nifurtimox Side EffectsAbdominal pain, Anorexia, Central and Peripheral Nervous system toxicity