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level: Level 1 of TABLETS

Questions and Answers List

level questions: Level 1 of TABLETS

QuestionAnswer
TYPES OF TABLETS1 Compressed Tablets 2 Multiply Compressed Tablets 3 Sugarcoated tablets 4 Film Coated Tablets 5 Gelatin-coated Tablets 6 Enteric-coated Tablets 7 Buccal and Sublingual Tablets 8 Chewable Tablets 9 Effervescent Tablets 10 Molded Tablets 11 Tablet Triturates, 12 Hypodermic Tablets 13 Dispensing Tablets 14 Immediate Release Tablets 15 Extended Release Tablets 16 Vaginal Tablets, 17 Dissolving Tablets
ADVANTAGES OF TABLETS1 Large scale production at lowest cost 2 Easiest and cheapest to package and ship 3 High stability 4 Easy to handle 5 Lightest and most compact 6 Greatest dose precision and least variability 7 Coating can mark unpleasant taste and improve patient acceptability
1 add the necessary bulk to a formulation to prepare tablets of the desired size 2 promote adhesion of the particles of the formulation, allowing a granulation to be prepared and maintaining the integrity of the final tablet. 3 which promote breakup of the tablets after administration to smaller particles for ready drug availability1 Diluents or fillers 2 Binders or adhesives 3 Disintegrants or disintegrating agents
1 which enhance the flow of the material into the tablet dies, minimize wear of the punches and dies, prevent fill material from sticking to the punches and dies, and produce tablets with a sheen 2 such as colorants and flavorants.1 Antiadherents, glidants, lubricants, or lubricating agents 2 Miscellaneous adjuncts
1 are prepared by subjecting the fill material to more than a single compression. 2 may be coated with a colored or an uncolored sugar later1 Multiply compressed tablets 2 SUGARCOATED TABLETS
1 Purpose of sugarcoat 2 Disadvantage of sugarcoat1 - Protection from environment - enhance appearance; permits imprinting 2 -time and expertise required -may add 50% to the weight and bulk of the uncoated tablet.
1 compressed tablets coated with a thin layer of a polymer capable of forming a skin-like film. 2 A recent innovation; capsule-shaped compressed tablet that allows the coated product to be about one-third smaller than a capsule filled with an equivalent amount of powder1 FILM-COATED TABLETS 2 GELATIN-COATED TABLETS
1 Gelatin-Coated innovator product 2 Gelatin-Coated compared to unsealed tablets1 gelcap 2 -more tamper evident Ex. Tylenol Cold MultiSymptom Daytime (McNeil Consumer)
1 have delayed-release features. designed to pass unchanged through the stomach to the intestines 2 are flat, oval tablets intended to be dissolved in the buccal pouch or beneath the tongue 3 disc-shaped solid dosage forms containing a medicinal agent and generally a flavoring substance in a hard candy or sugar base.1 ENTERIC-COATED TABLETS 2 BUCCAL AND SUBLINGUAL TABLETS 3 Lozenges or troches
1 have a smooth, rapid disintegration when chewed or allowed to dissolve in the mouth, have a creamy base, usually of specially flavored and colored mannitol . 2 are prepared by compressing granular effervescent salts that release gas when in contact with water 3 can assist in breaking up the tablets and enhancing the dissolution of the active drug1 CHEWABLE TABLETS 2 EFFERVESCENT TABLETS 3 “bubble action”
1 may be prepared by molding rather than by compression. The resultant tablets are very soft and soluble and are designed for rapid dissolution 2 small, usually cylindrical. Molded or compressed tablets containing small amounts of usually potent drugs1 MOLDED TABLETS 2 TABLET TRITURATES
1 Diluents of tablet triturates 2 tablet triturates used sublingually 3 Pharmacists also employ it in compounding1 sucrose and lactose 2 nitroglycerin tablets 3 tablet triturates
1 no longer available in the United States. 2 Why hypodermic tablets are eliminated1 HYPODERMIC TABLETS 2 -difficulty achieving sterility -availability of prefabricated injected products
1 are no longer in use; contained large amounts of highly potent drug substances; highly toxic if taken orally by mistake 2 are designed to disintegrate and release their medication with no special rate-controlling features1 DISPENSING TABLETS 2 IMMEDIATE-RELEASE TABLETS
1 Dispensing tablets are termed as __ 2 The medicaments commonly incorporated in dispensing tablets:1 compounding tablets 2 -mild silver proteinate, -bichloride of mercury -merbromin and -quaternary ammonium compounds
1 are designed to release their medication in a predetermined manner over an extended period 2 uncoated, bullet-shaped or ovoid tablets inserted into the vagina for local effects.1 EXTENDED-RELEASE TABLETS 2 Vaginal tablets (vaginal inserts)
1 Vaginal tablets contain1 Antibacterials (vaginitis caused by Haemophilus vaginalis) 2 Antifungals (vulvovaginitis candidiasis caused by Candida albicans)
1 are characterized by disintegrating or dissolving in the mouth within 1 minute, some within 10 seconds1 Instant-release tablets (rapidly dissolving tablets, or RTDs)
1 Instant-release tablets disadvantages 2 A number of techniques are used to prepare these DISSOLVING TABLETS1 ✓ Drug loading ✓ Taste masking ✓ Friability ✓ Manufacturing costs ✓ Stability of the product 2 ✓ Lyophilization ✓ Soft direct compression