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Questions and Answers List

level questions: Easy

QuestionAnswer
due to decresed hemoglobin productionmicrocytic anemia
Hemoglobin compositionheme + globin
Heme compositioniron+ protophorphrin
Most common type of anemiairon deficiency anemia
Most common nutritional deficiency in the worldiron deficiency
transports iron across the cell membrane into the bloodFerroportin
transports iron in the blood and delivers it to liver and bone marrow macrophages for storageTransferrin
Binds intracellular stored iron and prevents iron from forming free radicals via the Fenton reactionFerritin
primary cause of iron-deficiency anemia among elderly in the developing worldAncyclostoma duodenale and Necator americanus
primary cause of iron-deficiency anemia among elderly in the Western worldColon polyps/carcinoma
most common type of anemia in hospitalized patientsAnemia of chronic disease
sequesters iron in storage sites in times of chronic inflammationHepcidin
anemia due to defective protoporphyrin synthesisSideroblastic anemia
Where does the final reaction of heme synthesis occur?Mitochondria
ALAD and Ferrochelatase inhibitorLead
cells with iron-laden mitochondria forming a ring around the nucleus of erythroid precursorsRinged sideroblasts
Most commonly seen side effect of isoniazid leading to sideroblastic anemiaVitamin B6 deficiency
anemia due to decreased synthesis of the globin chains of hemoglobinThalassemia
globin composition of HbFα2γ2
globin composition of HbAα2β2
globin composition of HbA2α2δ2
major cause of α-thalassemiagene deletion
major cause of β-thalassemiagene mutation
Skull x-ray finding in Thalessemia and sickle cell anemia shown in the pictureCrew-cut appearace
Two most common causes of macrocytic anemiaFolate or Vitamin B12 deficiency
In what part of the small intestine is folate absorbed?Jejunum
this drug is a folate antagonist whose main mechanism of action is to inhibit dihydrofolate reductaseMethothrexate
protein that binds Vitamin B12 when it is liberated by the salivary glands in the mouthR-binder
detaches vitamin B12 from the R-binderPancreatic proteases
binds Vitamin B12 in the small intestineintrinsic factor
segment of the small intestine where the vitamin B12-IF complex is absorbedileum
cells that produce intrinsic factorgastric parietal cells
most common cause of Vitamin B12 deficiencypernicious anemia
autoimmune destruction of parietal cellspernicious anemia
inherited defect of RBC cytoskeleton-membrane tethering proteinsHereditary spherocytosis
Test which reveals increased spherocyte fragility in hypotonic solutionosmotic fragility test
fragments of nuclear material in RBCs which emerges after splenectomyHowell-Jolly bodies
autosomal recessive mutation in beta chain of hemoglobinSickle cell anemia
replaces the normal glutamic acid in sickle cell anemiavaline
acquireid defect in myeloid stem cells resulting in absent glycosylphosphatidylinositol (GPI)Paroxysmal nocturnal hemoglobinuria
What segment of the small intestine does iron absorption occursduodenum