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level: DRUG TARGET AND DRUG DESIGN

Questions and Answers List

level questions: DRUG TARGET AND DRUG DESIGN

QuestionAnswer
Receptor Used as Drug Target1 M acetylcholine receptor 2 adrenergic receptor 3 angiotensin receptor 4 dopamine receptor 5 serotonin receptor 6 opioid receptor
Drugs effecting on receptors1 Agonist 2 Antagonist 3 Partial agonist
These are drugs that occupy receptors and activate themAgonists
Drugs that occupy receptors but do not activate them, but they block cellular activityAntagonists
It has less activation or less cellular activityPartial Agonist
ACE Inhibitors block what?Block Angiotensin I from converting into Angiotensin II
AT1 receptor effects1 Vasoconstriction 2 Sympathetic activation 3 Cell proliferation 4 Aldosterone release 5 Renal sodium resorption
AT2 receptor effects1 Vasodilation 2 Inhibition of cell growth 3 Apoptosis
Which receptor leads to Atherosclerosis, Hypertension?AT1 receptor
Lower blood pressure and increase blood to heartARBs
Adrenergic Receptors1 Alpha-1 2 Alpha-2 3 Beta-1 (Heart and Kidneys) 4 Beta-2 (Lungs)
Alpha 2 Inhibits what?1 Norepinephrine release 2 Acetylcholine release 3 Insulin release
Types of Enzymes as Drug Target1 Angiotensin Converting Enzyme (ACE) 2 Cycloxygenase (COX2) 3 β-Lactamase 4 Acetylcholine Esterase
Drugs effecting on enzymeEnzyme Inhibitor
Enzyme present in bacteriaLactamase - can degrade penicillin
ACE Inhibitor effects1 Dry cough 2 Increase Bradykinin
HMG CoA Reductase Inhibitors1 Pravastatin 2 Lovastatin
Blocks calcium access to cellsCalcium Channel Blockers, less contractility less conductivity to the heart
Drugs Affecting on Ion Channel1 Calcium Channel Blocker 2 Potassium Channel Blocker 3 Sodium Channel Blocker
They bind to two nuclear enzymes, inhibiting DNA replicationFluoroquinolones
Ion Channels1 Calcium Ion Channel 2 Potassium Ion Channel 3 Sodium Ion Channel 4 Chloride Ion Channel