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level: Monoclonal Antibodies

Questions and Answers List

level questions: Monoclonal Antibodies

QuestionAnswer
NANA
How are Antibodies made?-They are made from a B-Lymphocyte Cell. Simple
What do Monoclonal Antibodies do that is Different? Why?-Monoclonal Antibodies are made from Clones, Lots of Clones, of a Single White Blood Cell. -This makes a Stupid Amount of Antibodies that will target 1 Antigen.
Why and How do we make Monoclonal Antibodies?-B-Lymphocytes Cells don't really Divide Easily, so its Hard to get Lots of Clones; Tumour Cells, however, Divide very Quickly but make 0 Antibodies. -And, we can Fuse a MOUSE Lymphocyte Cell with a Tumour Cell to create a New Cell: Hybridoma. -Hybridoma can Replicate and Clone it selves very Quickly, which can make 1 Single Specific Antibody. This, the Cells, are Collected and Purified -Monoclonal Antibodies are Useful for only Targeting a Specific Molecule, or Cell - so you Use it in your Body for a Cell or Chemical.
What happens, using Information about Monoclonal Antibodies, in a Pregnancy Test if you are Positive?-If you are Pregnant, then your Urine will have a Hormone [HCG] -The Bit where you Wee on will have Antibodies to HCG, that itself has Blue Beads Attached. -As you Pee, HCG will Bind onto the Antibodies, and Move because of the Liquid [Your Piss] -It then will reach the Strip, where there is More Antibodies for the Hormone, with the Difference being they are Stationary. -So HCG will Bind on to that Still Antibody, and will get Stuck - and the Blue Beads that is now also Stuck will begin to make a Blue Line on the Test Strip - Saying you are Pregnant!!
What happens, using Information about Monoclonal Antibodies, in a Pregnancy Test if you are Negative?-If you are not Pregnant, you will Not have the Hormone in your Urine [HCG] -So when you Wee, the Antibodies with the Blue Beads Attached will go up the Strip but will not Bind onto Anything, because HCG is not Present. -When it Reaches the Test Strip, again, Nothing Happens because HCG isn't Present to Bind on - so the Still Antibodies do NOT Stop the Mobile Antibodies with the Blue Beads meaning that the Test Strip will not show a Blue Line - you are Not Pregnant.
Why can Monoclonal Antibodies be Used to Treat Cancer? Why can't we use the Immune System?-Cancer Cells have Antigens, sure, but its Antigens aren't Found on Normal Body Cells - this is a Tumour Markers -And, Cancer Cells are made by the Body so therefore aren't 'Foreign' for the Body meaning the Immune System will do Nothing -However, Monoclonal Antibodies can be Made to Bind onto the Tumour Markers, Effectively Treating Cancer.
How can Monoclonal Antibodies be Used to Diagnose Cancer?-Give the Antibodies a Radioactive Element [Physics!!] -Give the now Radioactive Antibodies to the Patient via a Drip which allows it to go in the Blood and therefore Everywhere -When it Finds a Cancer Cell, it will Bind onto that Tumour Marker -A Picture can be Formed via some Camera that will Show the Radioactivity as a Bright Spot [So Bright Spot = Cancer Cell] -You can then see Where, How Big and If its Growing beyond.
How can Monoclonal Antibodies be Used to Target Drugs to Cancer Cells?-Anti-Cancer Drug is Attached to a Monoclonal Antibody. The Drug can be Radioactive or to Prevent it from Growing -Given to the Patient via a Drip [Into the Blood] -Antibodies will be Specific to the Cancer Cells - they only like Tumour Markers -The Drugs will Kill the Cancer Cells, no one Else -This may be Better than Radiotherapy and Chemotherapy because those 2 Methods may Damage Body Cells - Allowing worse Side Effects.
How even can Cancer Happen?-Cells, when Divided a Number of Times will Stop -However, a Mutation in the Genes that Controls the Cell Division can Grow in a Way that is Unprecedented -Mitosis keeps on Happening which will lead to a Tumour; Cancer is a Tumour that will Invade other Tissues.