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level: BRUCELLA

Questions and Answers List

level questions: BRUCELLA

QuestionAnswer
Brucellosis is bacteria infection contracted from due to unpasturised dairy products. what is the microscopic characteristic of the organism involved?Brucella species: gram negative coccobacillus. occupational disease of vets.
incubation period of Brucela sp5days-several weeks. presents an undulating fever pattern.
various sp of brucella includeB. abortus: cattle and buffalomost important cause of human brucellosis in Uk B melitensis: sheep and goat: malta and mediterranean fever and potentia agent for bio terrorism. B Suis : pigs: common in swine rearing areas in US. B. Canis: dog: common in dog handlers.Treat with Minocycline and streptomycin.
virulence factors of BrucellaLippopolysaccharide.
clinical presentation of Brucella infectionacute infection is non specific and chronic infection in incompletely treated patients. duration of illness: weeks- months.
lab diagnosisblood culture: serolgicall: four-fold rise in titre and 1:640 or more i acute disease. ELISA in animal: atibody in milk by milk ring test and rose bengal test.
treatmentgold standard: doxycycline plus streptomycin gentamycin for 3-4 wks doxycycline plus rifapin for 4-6wks rifampin plus cipro: who therapy. relapse is common on therapy with singe dose.
primary preventionminimal exposure and pasturisation of dairy product. vaccinatio for animals. no vaccine for humans.