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level: 1.9 Enzyme inhibition

Questions and Answers List

level questions: 1.9 Enzyme inhibition

QuestionAnswer
Competitive inhibition- Similar shape to substrates - Compete with substrates to bind to active site - No reaction takes place - Blocks active site instead - Forms enzyme-inhibitor complex
Competitive inhibition and concentration- How much the enzyme is inhibited depends on the relative concentrations of the inhibitor and the substrate - High concentration of inhibitor = more blocking of the active sites - High concentration of substrate = less blocking of the active sites, increasing rates of reaction
Non-competitive inhibition- Binds to the enzyme away from its active site (allosteric site) - Changes shape of active site - Substrates can no longer bind to enzyme - They don't 'compete' as they are different shape
Site that non-competitive binds to- Allosteric site
Non-competitive inhibition and concentration- Increasing substrate concentration wont make a difference to the reaction rate
What is End Product Inhibition (inhibition feedback)- When the end product of the series of enzyme controlled reactions will inhibit the first enzyme in the series - To stop the reaction - Often non-competitive inhibition
Non-competitive inhibition and rates of reaction (in terms of feedback)- Non-competitive inhibitors always slow rates of reaction - Controls reaction
Competitive inhibition and rates of reaction (in terms of feedback)- Competitive inhibitors don't slow down the rate of reaction if the substrate concentration is high - So it cant control the reaction