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level: Systemic adverse drug reactions

Questions and Answers List

level questions: Systemic adverse drug reactions

QuestionAnswer
What is a type A ADREffects of medication greater than needed are dose related predictable Variants: E.g. digoxin toxicity, hypnotics leading to sedation, beta blockers causing bradycardia
Biggest cause of angiodema in A&EACE inhibitor angiodema
Warfarin adverse outcome of lack of drug monitoringElevated INR
What is INRIndicated time for a blood clot to form normally around 1.1 if taking warfarin can be 2-3 if higher clot formation is too slow
Type B ADRs areBizare not dose realted uncommon and unrelated to pharmacology can be fatal e.g. penicillin hypersensitivty malignant hyperthermia
Type C ADRDose and time related somewhat uncommon but are the culmulative effect of drug ie. too much paracetamol in 48 hours
Type D ADRDelayed reaction e.g. time related are uncommon and dose related
Type E ADR reactions areAs the result of end use withdrawal symptome
Type Fcommon dose related caused by drug interactions
What is anaphylaxisAnaphylaxis causes a series of symptoms including rash, low pusle and shock