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level: Bisphosphonates and other antiresorptives

Questions and Answers List

level questions: Bisphosphonates and other antiresorptives

QuestionAnswer
Drugs to be aware ofOral- alendronate, risedronate, clodronate and ibandronate
Most commmon bisphosphonateAlendronate
What happens if osteoclasts are over supressedGet accumulation of microdamage brittleness can occur and MRONJ can occur
What are BPs used forOsteoporosis, metastatic cnacers, OI, pagets, hypercalcaemia/ primary hyperparathyroidism
What type of patient is likely to be on higher doses of denusomabCancer patients
MRONJ stages0=not exposed
BPsadvise of small risk of MRONJ
How many years of BP use does MRONJ risk increase5 years- warn patient of this
If extraction site has not healed after how long should you refer8 weeks
High risk of MRONJ-Previous diagnosis, on systemic corticosteroids in addition to BP or 9 months plus denusoumab, anti resoptive or anti angiogenic drugs for cancer management. Or on BP for 5 years
What cancers make the risk worseMultiple myeloma/ prostate cancer
Risk for patients taking due to osteoporosis/pagets disease MRONJ risk is0.1% or less
What can also cause MRONJPoorly fitting denture