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level: Anti depressants

Questions and Answers List

level questions: Anti depressants

QuestionAnswer
What is clorygylineA selective MAO-A inhibitor has dietary side effects
What is moclobemideA reversible MAO-A inhibitor no dietary side affects amplifies 5HT and NA
Tricyclics work byAmplyfying NA and 5HT but has chollinergic side effects
What is reboxetineit is a NASRI- no antichollinergic side effects
What is citalopramA SSRI- no antichollinergic side effects
What is venlafaxineA combined SSRI- amplifies 5HT and NA no antichollinergic side effects
What is busipironeA atypical antidepressant free of major trycyclic side effects stimultes 5HT1A receptors
What is mirtazapineAn atypical antidepressant works by disinhibiting NA/5HT by blocking inhibitory receptors
What do trycyclics doBlock the reuptake of monoamines - but also blocks the reuptake of histamine and dopamine
What side effects do dual 5HT and NA haveUnwanted cardiac affects due to blockade no NA
What causes the MAOs side effectsThese enzymes nomrally break down NA and 5HT as they can no longer do this have normal side effect of increased NA whcih can cause hypertension and dietary impairment
When are atypicals usedWhen the usuals havent worked try atypical as works via a different mechanism
SSRI examplesSertraline, fluxotine, citalopram, escitalpram, paroxetine, fluvoaxamine
Side effect of TCAs dentally relevantDry mouth plus poor dental health
Examples of antidepressantsAmitrptyline, #clomipramine#, dosulpein, iipramime, lefepramime, nortiptyline and doxepin
Venlafaxine and duloxetine areSNRIs for depression anxiety causes dry mouth
Mirtazepine isA antagonist at central pre synaptic alpha 2 rectors increases 5HT and NA
NSAIDs+ SSRIsIncreased risk of GI bleeding ok for 2-4 days but avoid in elderly and at risk
Codeine and SSRIsPoor analgesia due to interaction therefore use morphine
Benzos- treat anxiety and alchohol withdrawal + SSRIsInhibit oxidation of benzos so get raised levels therefore use Lorazepam or temazepam
Tramadol and meperidine (strong analgesics) plus SSRIscan cause serotonin syndrome- muscle rigidity and shakes plus diarhhoea
Epinephrine plus levonodefrin+ MAOIsEphedrine and nasal congestion may lead to hypertensive crisis
Adrenaline plus levonodfrin + TCAsSympathomimetic actions recheck vital signs after use