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level: Anti-viral drugs

Questions and Answers List

level questions: Anti-viral drugs

QuestionAnswer
Oseltamavir and tamiflu work viaInhibiting neuraminidase which breaks bond allowing virus to leave the cell
What is aciclovir used for:Herpes simplex I II and zoster, is a pro-drug as is phosphorylated by viruses TK which is more active than the hosts
Reverse transcriptase inhibitors are used forHIV
Raltegravir is anIntegrase inhibitor
Lopinavir works byInhibiting HIV protease which cleaves viral protein into its two functional units
Regime for AIDS2 nucleoside RT inhibitors plus one of- non nucleoside RT inhibitors, boosted protease inhibitor, and integrase inhibitor and a chemokine recptor antagonist
Superficial vs systemic fungal infectionsCandidiasis- candida albicans
Amphotericin is aantifungal
Nystatin- similar mechanism as amphotericin butTopical for candida albicans
Azoles work byinhibiting synthesis of ergosterol therefore less hyphae formation
Superficial infections are treated withImidazoles- for tinea and candida topical application or oral for nail/skin infections
Systemic infections are treated withTriazoles e.g. fluconazole via oral or IV enter CSF
Terbinafine is used forSuperficial infections especially nail can be used topically or orally works