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level: Autonomic pharmacology

Questions and Answers List

level questions: Autonomic pharmacology

QuestionAnswer
Hemicholinium- no clin. uses mechanismCompetitive inhibitor of the choline carrier
ChAT inhibitors used clinicallyNo
Vesamicol works byPreventing storage of ACh (via vesicular ACh transporter)
Bottulin toxin preventsExocytosis
Bottulin used to treatSalivary dlrooling
Neostigmine and physostigmine are-Cholinesterase inhibitors
Suxamenthonium works byAgonising nicotinic receptors over two sub parts of the receptor which desensitises the receptors cauisng paralsysis
What are butylcholinesterasesNon specific cholinesterases
Complication with suxamenthoniumIs broken down by butrycholinesterases some individuals genetically lack this systemic enzyme meaning suxamenthoniuma has a paralysising effect
What are galantamine and rivastigimineNicotinic allosteric potentiating ligands
Decarmethonium is selective forNicotinic skeletal muscle
Antimuscarinics work viaInhibition of parasympathetic nervous system
Are drugs specific to muscarinic subtypes usedNo
What is ipratropium used forAsthma
What is atropine used to treatbradycardia
Pirenzepine is used todecrease gut motility and secretions
Why is atropine given presurgeryDecreases secretions therefore decreasing AChEI side effects
What is tropicamide used forPupil dilation
Oxybutynin is used forUrinary incontinence
What is hyoscine used formotion sickness