Why use Pharmacokinetic models?

1 To stimulate the RATE PROCESS of drug ADME to predict drug concentration in the body 2 Predict plasma, tissue, and urine drug level with any dosage regimen 3 Calculate the optimum dosage regimen for each patient individually 4 Estimate the possible accumulation of drugs and metabolites 5 Correlate drug concentration with pharmacologic or toxicologic activity 6 Evaluate differences in the rate or extent of availability between formulations (bioequivalence) 7 describe how changes in physiology or disease affect the absorption, distribution or elimination of the drug 8 explain drug interaction