PHARMACOLOGY 1: •N-acetyl-p-aminophenol (APAP)

•MOA: inhibits prostaglandin synthesis
in the CNS (analgesic and antipyretic)

•LESS EFFECT ON COX in PERIPHERAL TISSUES (due to peripheral inactivation), which accounts for its WEAK
ANTI-INFLAMMATORY ACTIVITY (not an NSAID)

Question

•N-acetyl-p-aminophenol (APAP)

•MOA: inhibits prostaglandin synthesis 
in the CNS (analgesic and antipyretic)

•LESS EFFECT ON COX in  PERIPHERAL TISSUES (due to peripheral  inactivation), which accounts for its WEAK 
ANTI-INFLAMMATORY ACTIVITY (not an NSAID)

LEIGHTON DWIGHT OBILLOS · Accepted Answer

ACETAMINOPHEN

•N-acetyl-p-aminophenol (APAP) •MOA: inhibits prostaglandin synthesis in the CNS (analgesic and antipyretic) •LESS EFFECT ON COX in PERIPHERAL TISSUES (due to peripheral inactivation), which accounts for its WEAK ANTI-INFLAMMATORY ACTIVITY (not an NSAID)