Advantages of Rectal Administration

1. Avoidance of first-pass effect 2. Drug stability- avoiding breakdown of drugs that are susceptible to gastric degradation 3. Large dose drugs: Ability to administer somewhat large dose of drugs than oral administration 4. Irritating drugs: ability to administer drugs that have an irritating effect on the oral or GI mucosa 5. Unpleasant tasting and smelling drugs 6. Rectal route is especially useful for children 7. Patient experiencing nausea and vomiting, unconscious 8. Presence of dx of the upper GI tract that interferes drug absorptions 9. Objectional taste or odor of a drug ( impt. in children) 10. Achievement of rapid drug effect systemically (alternate to injection)